What Is Chemosaturation Therapy?

Chemosaturation of the liver represents an evolution from a highly invasive open surgical procedure to a minimally invasive procedure for treating patients with cancers in the liver.

In hepatic chemosaturation therapy, a percutaneous hepatic perfusion (PHP) procedure delivers ultra-high doses of intra-arterial chemotherapy directly into the isolated liver, saturating both the liver and the tumor cells. The blood from the liver is drained through an isolation-aspiration catheter, and then directed outside the body to proprietary filters, which reduce the concentration of chemotherapeutic agent before this blood is returned to the body.

The potential of chemosaturation therapy includes:

• The ability to administer higher doses of chemotherapeutic agent to a particular organ than could be delivered with traditional systemic-intravenous methods
• Significant reduction of systemic exposure to the higher dose levels
• The potential to complement existing systemic treatments for primary disease